2022年度
  • Chen X, Furukawa N, Jin DY, Liu Yizhou, Stafford DW, Williams CM, Suhara Y, Tie JK. Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation. FEBS J, 289(9), 2613-2627, 2022. doi: 10.1111/febs.16291.
2021年度
  • Chen X, Liu Y, Furukawa N, Jin DY, Paul SG, Stafford DW, Suhara Y, Williams CM, Tie JK. A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. J Thromb Haemost 19(3), 689-700, 2021. doi: 10.1111/jth.15209.
  • Terui R, Yanase Y, Yokoo H, Suhara Y, Makishima M, Demizu Y, Misawa T. Development of Selective TGR5 Ligands Based on the 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene Skeleton. ChemMedChem, 16(3), 458-462, 2021. doi: 10.1002/cmdc.202000567.
2020年度
  1. Chen X, Liu Y, Furukawa N, Jin DY, Savage GP, Stafford DW, Suhara Y, Williams CM, Tie JK. A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. 2020. doi: 10.1111/jth.15209.
  1. Terui R, Yanase Y, Yokoo H, Suhara Y, Makishima M, Demizu Y, Misawa T. Development of Selective TGR5 Ligands Based on the 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene Skeleton. ChemMedChem, 2020. doi: 10.1002/cmdc.202000567.
  1. Yoshimura H, Hirota Y, Soda S, Okazeri M, Takagi Y, Takeuchi A, Tode C, Kamao M, Osakabe N, Suhara Y.* Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity. Bioorg Med Chem Lett, 30(8), 127059, 2020. doi: 10.1016/j.bmcl.2020.127059.
2019年度
  1. Nishioka T, Endo-Umeda K, Ito Y, Shimoda A, Takeuchi A, Tode C, Hirota Y, Osakabe N, Makishima M, Suhara Y.* Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives. Molecules. 24(23), E4316, 2019. doi: 10.3390/molecules24234316.
  1. Fujii Y, Suhara Y, Sukikara Y, Teshima T, Hirota Y, Yoshimura K, Osakabe N.* Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity. Molecules. 24(20), E3667, 2019. doi: 10.3390/molecules24203667.
  1. Hirota Y, Suhara Y.* New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity. Int J Mol Sci. 20(12), E3006, 2019. doi: 10.3390/ijms20123006.
  1. Nakagawa K, Fujiwara K, Nishimura A, Murakami C, Kawamoto K, Ichinose C, Kunitou Y, Suhara Y, Okano T, Hasegawa H.* UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells. Int J Mol Sci. 20(8), E1971, 2019. doi: 10.3390/ijms20081971.
2018年度
  1. Hirota, Y.; Nakagawa, K.; Isomoto, K.; Sasaki, T.; Kubodera, N.; Kamao, M.; Osakabe, N.; Suhara, Y.; Okano, T.* Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice. PLoS One. 13(10), e0199856, 2018. doi: 10.1371/journal.pone.0199856.
  1. Nakagawa, Y.; Ishimura, K.; Oya, S.; Kamino, M.; Fujii, Y.; Nanba, F.; Toda, T.; Ishii, T.; Adachi, T.; Suhara, Y.; Osakabe, N.* Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice. PLoS One. 13(7), e0201203, 2018. doi: 10.1371/journal.pone.0201203.
2017年度
  1. Sakane, R.; Kimura, K.; Hirota, Y.; Ishizawa, M.; Takagi, Y.; Wada, A.; Kuwahara, S.; Makishima, M.; Suhara, Y.*  Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities. Bioorg. Med. Chem. Lett. 27(21), 4881-4884, 2017. doi: 10.1016/j.bmcl.2017.09.038.
  1. Kamao, M.; Hirota, Y.; Suhara, Y.; Tsugawa, N.; Nakagawa, K.; Okano, T.; Hasegawa, H.* Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring. Anal Sci. 33(7), 863-867, 2017. doi: 10.2116/analsci.33.863.
  1. Kimura, K.; Hirota, Y.; Kuwahara, S.; Takeuchi, A.; Tode, C.; Wada, A.; Osakabe, N.; Suhara, Y.* Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells. J. Med. Chem. 60(6), 2591-2596, 2017. doi: 10.1021/acs.jmedchem.6b01717.
  1. Ikeda, M.; Ueda-Wakagi, M.; Hayashibara, K.; Kitano, R.; Kawase, M.; Kaihatsu, K.; Kato, N.; Suhara, Y.; Osakabe, N.; Ashida, H.* Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin. Molecules, 22(2), E314, 2017. doi: 10.3390/molecules22020314.
  1. Hirota, Y; Nakagawa, K.; Mimatsu, S.; Sawada, N,.; Sasaki, T.; Kubodera, N.; Kamao, M.; Tsugawa, N.; Suhara, Y.; Okano, T. Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and VDR knockout mice. Biochem. Biophys. Res. Commun. 483 (1), 359-365, 2017. doi: 10.1016/j.bbrc.2016.12.139.
2016年度
  1. SAITO, A.; NAKAZATO, R.; SUHARA, Y.; SHIBATA, M.; FUKUI, T.; ISHII, T.; ASANUMA, T.; MOCHIZUKI, K.; NAKAYAMA, T.; OSAKABE, N. The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials. J. Nutr. Biochem. 107-114, 2016.
  1. KAMIO, N.; SUZUKI, T.; WATANABE, Y.; SUHARA, Y.; OSAKABE, N. A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice. Free Radic. Biol. Med. 256-263, 2016.
2015年度
  1. KUDO, N.; ARAI, Y.; SUHARA, Y.; ISHII, T.; NAKAYAMA, T.; OSAKABE, N. A Single Oral Administration of Theaflavins Increases Energy Expenditure and the Expression of Metabolic Genes. PLos One 10(9), e0137809, 2015.
  1. SUHARA, Y.; HIROTA, Y.; HANADA, N.; NISHINA, S.; EGUCHI, S.; SAKANE, R.; NAKAGAWA, K.; WADA, A.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T. Synthetic small molecules derived from natural vitamin K homologues that induce selective neuronal differentiation of neuronal progenitor cells. J. Med. Chem. 58(17), 7088-7092, 2015.
  1. HIROTA, Y.; NAKAGAWA, K.; SAWADA, N.; OKUDA, N.; SUHARA, Y.; UCHINO, Y.; KIMOTO, T.; FUNAHASHI, N.; KAMAO, M.; TSUGAWA, N.; OKANO, T. Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. PLoS One. 10(4), e0125737, 2015.
  1. FUNAHASHI, N.; HIROTA, Y.; NAKAGAWA, K.; SAWADA, N.; WATANABE, M.; SUHARA, Y.; OKANO, T. YY1 positively regulates human UBIAD1 expression. Biochem. Biophys. Res. Commun. 460(2), 238-244, 2015.
2014年度
  1. NAKAGAWA, K.; SAWADA, N.; HIROTA, Y.; UCHINO, Y.; SUHARA, Y.; HASEGAWA, T.; AMIZUKA, N.; OKAMOTO, T.; TSUGAWA, N.; KAMAO, M.; FUNAHASHI, N.; OKANO, T. Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice. PLoS One, 15;9(8), e104078, 2014.
2013年度
  1. HIROTA, Y.; TSUGAWA, N.; NAKAGAWA, K.; SUHARA, Y.; UCHINO, Y.; TAKEUCHI, A.; SAWADA, N.; KAMAO, M.; WADA, A.; OKITSU, T.; OKANO, T. Menadione (vitamin K3) is not only a catabolic product of oral phylloquinone (vitamin K1) in the intestine but also a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. J. Biol. Chem. 288(46), 33071-33080, 2013.
  1. EDOSON, K.; PSARAD, B.; UNADKAT, J.; SUHARA, Y.; OKANO, T.; GUENGERICH, F.; RETTIE, A. Cytochrome P450-Dependent Catabolism of Vitamin K: ω-Hydroxylation Catalyzed by Human CYP4F2 and CYP4F11. Biochemistry 52, 8276-8285, 2013.
  1. LI, Q.; QI, J.; WU, Y.; KIYOTA, H.; TANAKA, K.; SUHARA, Y.; OHRUI, H.; SUZUKI, Y.; VAVRICKA, C. J.; GAO, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers fuether insight into the mechanism of oseltamivir resistance. J. Virol. 87(16), 10016-10024, 2013.
2012年度
  1. SUHARA, Y.; HANADA, N.; OKITSU, T.; SAKAI, M.; WATANABE, M.; NAKAGAWA, K.; WADA, A.; TAKEDA, K.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T. Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities. J. Med. Chem. 55, 1553-1558, 2012.
2011年度
  1. SUHARA, Y.; WATANABE, M.; MOTOYOSHI, S.; NAKAGAWA, K.; WADA, A.; TAKEDA, K.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T. Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K. J. Med. Chem. 54, 4918-4922, 2011.
  1. SUHARA, Y.; WATANABE, M.; NAKAGWA, K.; WADA, A.; ITO, Y.; TAKEDA, K.; TAKAHASHI, K.; OKANO, T. Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists. J. Med. Chem. 54, 4269-4273, 2011.
2010年度
  1. NAKAGAWA, K.; HIROTA, Y.; SAWADA, N.; YUGE, N.; WATANABE, M.; UCHINO, Y.; OKUDA, N.; SHIMOMURA, Y.; SUHARA, Y.; OKANO, T. Identification of UBIAD1 as a Novel Human Menaquinone-4 Biosynthesis Enzyme. Nature 468, 117-121, 2010.
  1. WADA, A.; WANG, F.; SUHARA, Y.; YAMANO, Y; OKITSU T.; NAKAGAWA, K.; OKANO, T. Efficient Synthesis and Biological Evaluation of Demethyl Geranylgeranoic Acid Derivatives. Bioorg. Med. Chem. 18(16), 5795-5806, 2010.
  1. SUHARA, Y.; WADA, A.; TACHIBANA, Y.; WATANABE, M.; NAKAMURA, K.; NAKAGAWA, K.; OKANO, T. Structure-activity Relationships in the Conversion of Vitamin K Analogues into Menaquinone-4. Substrates Essential to the Synthesis of Menaquinone-4 in Cultured Human Cell Lines. Bioorg. Med. Chem. 18(9), 3116-3124, 2010.
2009年度
  1. SAITO, N.; SUHARA, Y.; ABE, D.; KUSUDO, T.; OHTA, M.; SAKAKI, T.; HONZAWA, S.; FUJISHIMA, T.; KITTAKA, A. Synthesis of 2α-Propoxy-1α,25- dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1. Bioorg. Med. Chem. 17(13), 4296-4301, 2009.
  1. SUHARA, Y.; WADA, A.; OKANO, T. Elucidation of the Mechanism Producing Menaquinone-4 in Osteoblastic Cells. Bioorg. Med. Chem. Lett. 19, 1054-1057, 2009.
2008年度
  1. 岡野 登志夫；津川 尚子；須原 義智；中川 公恵；鎌尾 まや. 骨折予防からみたビタミンKの栄養状態. Osteoporosis Jpn. 16(2), 159-164, 2008.
  1. SUHARA, Y.; ABE, S.; MURAKAMI, A.; SHIMOMURA, Y.; NAKAGAWA, K.; KAMAO, M.; TUGAWA, N.; OKANO, T. Synthesis and Development of Biologically Active Fluorescent-labeled Vitamin K Analogues and Monitoring of their Subcellular Distribution. Tetrahedron 64, 8789-8796, 2008.
  1. SUHARA, Y.; HIROTA, Y.; NAKAGAWA, K.; KAMAO, M.; TSUGAWA, N.; OKANO, T. Design, Synthesis and Structure-activity Relationship of Vitamin K2 Analogues: Evaluation of their Biological Activities with Human Cultured Cell Lines. Bioorg. Med. Chem. 16(6), 3108-3117, 2008.
  1. OKANO, T.; SHIMOMURA, Y.; YAMANE, M.; SUHARA, Y.; KAMAO, M.; SUGIURA, M.; NAKAGAWA, K. Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE. J. Biol. Chem. 283(17), 11270-11279, 2008.
  1. TSUGAWA, N.; SHIRAKI, M.; SUHARA, Y.; KAMAO, M.; TANAKA, K.; OKANO, T. Vitamin K Status Is Associated with Vertebral Fracture in Japanese Women. J. Bone Miner. Metab. 26(1), 79-85, 2008.
2007年度
  1. KAMAO, M.; TSUGAWA, N.; SUHARA, Y.; WADA, A.; MORI, T.; MURATA, K.; NISHINO, R.; UKITA, T.; UENISHI, K.; TANAKA, K.; OKANO, T. Quantification of Fat-soluble Vitamins in Human Breast Milk by Liquid Chromatography-tandem Mass Spectrometry. J. Chromatogr. B 859, 192-200, 2007.
  1. KAMAO, M.; SUHARA, Y.; TSUGAWA, N.; UWANO, M.; YAMAGUCHI, N.; UENISHI, K.; ISHIDA, H. Vitamin K Content of Foods and Dietary Vitamin K Intake in Japanese Young Women. J. Ntr. Sci. Vitaminol. 53(6), 464-470, 2007.
  1. 白木 正孝；青木 長寿；山崎 典美；伊藤 喜久；津川 尚子；須原 義智；岡野 登志夫. 電気化学発光免疫法による血清中低カルボキシル化オステオカルシン(ucOC)測定キットの臨床的有用性の検討—カットオフ値の設定と骨粗鬆症患者におけるビタミンK2剤選択時の有用性の検討—. 医学と薬学, 57(4), 537-546, 2007.
  1. 中川 公恵；石橋 恵利子；須原 義智；大園 恵一；加藤 茂明；榊 利之；岡野 登志夫. 遺伝子改変細胞および遺伝子欠損動物を用いた骨形成作用におけるビタミンDとビタミンKの相互作用の解析. Osteoporosis Jpn. 15(4), 21-26, 2007.
  1. KAMAO, M.; TSUGAWA, N.; SUHARA, Y.; OKANO, T. Determination of Fat-Soluble Vitamins in Human Plasma, Breast Milk and Food Samples: Application in Nutrition Survey for Establishment of “Dietary Reference Intakes for Japanese”. J. Health Sci. 53(3), 257-262, 2007.
  1. SUHARA, Y.; MURAKAMI, A.; KAMAO, M.; NAKAGAWA, K.; TSUGAWA, N.; OKANO, T. Efficient Synthesis and Biological Evaluation of ω-Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites. Bioorg. Med. Chem. Lett. 17, 1622-1625, 2007.
  1. SUHARA, Y.; OKA, S.; KITTAKA, A.; TAKAYAMA, H.; WAKU, K.; SUGIURA, T. Synthesis and Biological Evaluation of Several Structural Analogs of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand. Bioorg. Med. Chem. 15, 854-867, 2007.
2006年度
  1. 津川尚子；鎌尾まや；須原義智；岡野登志夫. 血中25-ヒドロキシビタミンDの新規定量法の開発と臨床応用. Osteoporosis Jpn. 14(4), 25-30, 2006.
  1. TAKAHASHI, E.; NAKAGAWA, K.; SUHARA, Y.; KITTAKA, A.; NIHEI, K.; KONNO, K.; TAKAYAMA, H.; OKANO, T. Biological Activities of 2α-Substituted Analogues of 1α,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation. Biol. Pharm. Bull. 29(11), 2246-2250, 2006.
  1. HOURAI, S.; FUJISHIMA, T.; KITTAKA, A.; SUHARA, Y.; TAKAYAMA, H.; ROCHEL, N.; MORAS, D. Probing a Water Channel near the A-Ring of Receptor-Bound 1α,25-Dihydroxyvitamin D3 with Selected 2α-Substituted Analogues. J. Med. Chem. 49(17), 5199-5205, 2006.
  1. SUHARA, Y.; MURAKAMI, A.; NAKAGAWA, K.; MIZUGUCHI, Y.; OKANO, T. Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines. Bioorg. Med. Chem. 14, 6601-6607, 2006.
  1. SUHARA, Y.; KURIHARA, M.; KITTAKA, A.; ICHIKAWA, Y. Efficient Synthesis of Carbopeptoid Oligomers: Insight into Mimicry of β-Peptide. Tetrahedron 62, 8207-8217, 2006.
  1. TSUGAWA, N.; SHIRAKI, M.; SUHARA, Y.; KAMAO, M.; TANAKA, K.; OKANO, T. Vitamin K Status of Healthy Japanese Women; Age-related Vitamin K Requirement for γ-Carboxylation of Osteocalcin. Am. J. Clin. Nutr. 83, 380-386, 2006.
2005年度
  1. ABE, D.; SAKAKI, T.; KUSUDO, T.; KITTAKA, A.; SAITO, N.; SUHARA, Y.; FUJISHIMA, T.; TAKAYAMA, H.; HAMAMOTO, H.; KAMAKURA, M.; OHTA, M.; INOUYE, K. 2α-Propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-Hydroxypropoxy)-1α,25 -dihydroxyvitamin D3 by Human CYP27A1 and CYP24A1. Drug Metab. Dispos. 33(6), 778-784, 2005.
  1. TSUGAWA, N.; SUHARA, Y.; KAMAO, M.; OKANO, T. Method for the Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem. 77(9), 3001-3007, 2005.
  1. KAMAO, M.; SUHARA, Y.; TSUGAWA, N.; OKANO, T. Determination of plasma vitamin K by high-performance liquid chromatography with fluorescence detection using vitamin K analogs as internal standards. J. Chromatogr. B. 816(1-2), 41-48, 2005.
  1. SUHARA, Y.; KAMAO, M.; TSUGAWA, N.; OKANO, T. Method for the Detection of Vitamin K Homologues in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem. 77(3), 757-763, 2005.
2004年度
  1. SAITO, N.; SUHARA, Y.; KURIHARA, M.; FUJISHIMA, T.; HONZAWA, S.; TAKAYANAGI, H.; KOZONO, T.; MATSUMOTO, M.; OHMORI, M.; MIYATA, N.; TAKAYAMA, H.; KITTAKA, A. Design and Efficient Synthesis of 2α-(α-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity. J. Org. Chem. 69(22), 7463-7471, 2004.
  1. SUHARA, Y.; ONO, K.; YOSHIDA, A.; FUJISHIMA, T.; SAITO, N.; HONZAWA, S.; KISHIMOTO, S.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H.; KITTAKA, A.  Synthesis of Novel 1α,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate. Heterocycles 62, 423-436, 2004.
2003年度
  1. HONZAWA, S.; SUHARA, Y.; NIHEI, K.; SAITO, N.; KISHIMOTO, S.; FUJISHIMA, T.; KURIHARA, M.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H.; KITTAKA, A. Concise Synthesis and Biological Activities of 2α-Alkyl- and 2α-(α-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin  D3. Bioorg. Med. Chem. Lett. 13(20), 3503-3506, 2003.
  1. ONO, K.; YOSHIDA, A.; SAITO, N.; FUJISHIMA, T.; HONZAWA, S.; SUHARA, Y.; KISHIMOTO, S.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H.; KITTAKA, A.  Efficient Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells. J. Org. Chem. 68(19), 7407-7415, 2003.
  1. YOSHIDA, A.; ONO, K.; SUHARA, Y.; SAITO, N.; TAKAYAMA, H.; KITTAKA, A. Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2α- and 2α-Alkylated 1α,25-Dihydroxy-19-norvitamin D3 Analogues. Synlett (8), 1175-1179, 2003.
  1. OKA, S.; TSUCHIE, A.; TOKUMURA, A.; MURAMATSU, M.; SUHARA, Y.; TAKAYAMA, H.; WAKU, K.; SUGIURA, T. Ether-linked Analogue of 2-Arachidonoylglycerol (Noladin ether) was not Detected in the Brains of Various Mammalian Species. J. Neurochem. 85, 1374-1381, 2003.
  1. KITTAKA, A.; KURIHARA, M.; PLEG, S.; SUHARA, Y.; TAKAYAMA, H. 2α-(3-Hydroxypropyl)- and 2α-(3-Hydroxypropyl)-1α,25-dihydroxyvitaminD3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets. Chem. Pharm. Bull. 51(3), 357-8, 2003.
2002年度
  1. SUHARA, Y.; KITTAKA, A.; ONO, K.; FUJISHIMA, T.; YOSHIDA, A.; TAKAYAMA, H. Design and Efficient Syntheses of New Stable 1α,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond. Bioorg. Med. Chem. Lett. 12, 3533-3536, 2002.
  1. SUHARA, Y.; KITTAKA, A.; KISHIMOTO, S.; CALVERLEY, J. M.; FUJISHIMA, T.; SAITO, N.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H. Synthesis and Testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity. Bioorg. Med. Chem. Lett. 12, 3255-3258, 2002.
  1. SUHARA, Y.; YAMAGUCHI, Y.; COLLINS, B.; SCHNAAR, R. L.; YANAGISHITA, M.; HILDRETH, J. E. K.; SHIMADA, I.; ICHIKAWA, Y. Oligomers of Glycamino Acid. Bioorg. Med. Chem. 10(6), 1999-2013, 2002.
2001年度
  1. SUHARA, Y.; NIHEI, K.; KURIHARA, M.; KITTAKA, A.; YAMAGUCHI, K.; FUJISHIMA, T.; KONNO, K.; MIYATA, N.; TAKAYAMA, H. Efficient and Versatile Synthesis of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors. J.Org.Chem. 66(26), 8760-8771, 2001.
  1. SUHARA, Y.; NAKANE, S.; ARAI, S.; TAKAYAMA, H.; WAKU, K.; ISHIMA, Y.; SUGIURA, T. Synthesis and Biological Activities of Novel Structural Analogues of 2-Arachidonoylglycerol, An Endogenous Cannabinoid Receptor Ligand. Bioorg. Med. Chem. Lett. 11, 1985-1988, 2001.
2000年度
  1. KITTAKA, A.; SUHARA, Y.; TAKAYANAGI, H.; FUJISHIMA, T.; TAKAYAMA, H. A Concise and Efficient Route to 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor. Org. Lett. 2, 2619-2622, 2000.
  1. SUHARA, Y.; TAKAYAMA, H.; NAKANE, S.; MIYASHITA, T.; WAKU, K.; SUGIURA, T. Synthesis and Biological Activities of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, and Its Metabolically Stable Ether-linked Analogues. Chem. Pharm. Bull. 48(7), 903-907, 2000.
  1. SUHARA, Y.; NIHEI, K.; TANIGAWA, H.; FUJISHIMA, T.; KONNO, K.; NAKAGAWA, K.; OKANO, T.; TAKAYAMA, H. Synthesis and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues. Bioorg. Med. Chem. Lett. 10, 1129-1132, 2000.
  1. SUGIURA, T.; KONDO, S.; KISHIMOTO, S.; MIYASHITA, T.; NAKANE, S.; KODAKA, T.; SUHARA, Y.; TAKAYAMA, H.; WAKU, K. Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannnabinoid CB2 Receptor. J. Biol. Chem. 275(1), 605-612, 2000.
1999年度
  1. SUGIURA, T.; KODAKA, T.; NAKANE, S.; MIYASHITA, T.; KONDO, S.; SUHARA, Y.; TAKAYAMA, H.; WAKU, K.; SEKI, C.; BABA, N.; ISHIMA, Y. Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor. J. Biol. Chem. 274(5), 2794-2801, 1999.
1998年度
  1. IZUMI, M.; SUHARA, Y.; ICHIKAWA, Y. Design and Synthesis of Potential Inhibitors of Golgi Endo-α-D-mannosidase: 5-Thio-D-glucopyranosyl-α(1➝3)-1-deoxymannojirimycin and Methyl 5-Thio-D-glucopyranosyl-α(1➝3)-5-thio-α-D-mannopyranoside. J. Org. Chem. 63, 4811-4816, 1998.
  1. ICHIKAWA, Y.; IGARASHI, Y.; ICHIKAWA, M.; SUHARA, Y. 1-N-Iminosugars: Potent and Selective Inhibitors of β-Glycosidases. J. Am. Chem. Soc. 120(13), 3007-3018, 1998.
1997年度
  1. SUHARA, Y.; IZUMI, M.; ICHIKAWA, M.; PENNO, M.B.; ICHIKAWA, Y. Peptide-Sugar Hybrid: Like Peptide, Like Oligosaccharide. Tetrahedron Lett. 38, 7167-7170, 1997.
1996年度
  1. SUHARA, Y.; ICHIKAWA, M.; HILDRETH, J. E. K.; ICHIKAWA, Y. Synthesis of Sulfated β-1,6-Linked Oligosaccharide Mimetics: A Novel Potent Inhibitor of HIV Replication. Tetrahedron Lett. 37, 2549-2552, 1996.
  1. SUHARA, Y.; HILDRETH, J. E. K.; ICHIKAWA, Y. Synthesis of a New Carbohydrate Mimetics: “Carbopeptoid” Containing a C-1 Carboxylate and C-2 Amino Group. Tetrahedron Lett. 37, 1575-1578, 1996.
  1. SHIMIZU, T.; IWAMOTO, Y.; YANAGIHARA, Y.; RYOYAMA, K.; SUHARA, Y.; IKEDA, K.; ACHIWA, K. Comparison of the Biological Activity of Synthetic N-Acylated Asparagine or Serine Linked Monosaccharide Lipid A Analogues. Immunobiology 196(4), 321-331, 1996.
1995年度
  1. SUHARA, Y.; ACHIWA, K. Disaccharides as Endomannosidase Inhibitors: Synthesis of α-Homomannojirimycin and β-Homomannojirimycin Linked to D-Glucose and D-Mannose. Chem. Pharm. Bull. 43, 414-420, 1995.
1994年度
  1. SUHARA, Y.; ARAKAWA, M.; IKEDA, K.; ACHIWA, K. Lipid A and Related Compounds. XXIX.: Synthesis of Biologically Active N-Acylated L-Asparagine-Containing D-Glucosamine Derivatives Structually Related to Lipid A. Chem. Pharm. Bull. 42, 2526-2531, 1994.
  1. SUGIYAMA, K.; UEDA, H.; SUHARA, Y.; KAJIMA, Y.; ICHIO, Y.; YOKOTA, M. Protective Effect of Sodium L-Malate, an Active Constituent Isolated from Angelicae Radix, on cis-Diamminedichloroplatinum (II)-Induced Toxic Side Effect. Chem. Pharm. Bull. 42, 2565-2568, 1994.