Chen X, Furukawa N, Jin DY, Liu Yizhou, Stafford DW, Williams CM, Suhara Y, Tie JK. Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation. FEBS J, 289(9), 2613-2627, 2022. doi: 10.1111/febs.16291.
2021年度
Chen X, Liu Y, Furukawa N, Jin DY, Paul SG, Stafford DW, Suhara Y, Williams CM, Tie JK. A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. J Thromb Haemost 19(3), 689-700, 2021. doi: 10.1111/jth.15209.
Terui R, Yanase Y, Yokoo H, Suhara Y, Makishima M, Demizu Y, Misawa T. Development of Selective TGR5 Ligands Based on the 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene Skeleton. ChemMedChem, 16(3), 458-462, 2021. doi: 10.1002/cmdc.202000567.
2020年度
Chen X, Liu Y, Furukawa N, Jin DY, Savage GP, Stafford DW, Suhara Y, Williams CM, Tie JK. A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. 2020. doi: 10.1111/jth.15209.
Terui R, Yanase Y, Yokoo H, Suhara Y, Makishima M, Demizu Y, Misawa T. Development of Selective TGR5 Ligands Based on the 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene Skeleton. ChemMedChem, 2020. doi: 10.1002/cmdc.202000567.
Yoshimura H, Hirota Y, Soda S, Okazeri M, Takagi Y, Takeuchi A, Tode C, Kamao M, Osakabe N, Suhara Y.* Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity. Bioorg Med Chem Lett, 30(8), 127059, 2020. doi: 10.1016/j.bmcl.2020.127059.
2019年度
Nishioka T, Endo-Umeda K, Ito Y, Shimoda A, Takeuchi A, Tode C, Hirota Y, Osakabe N, Makishima M, Suhara Y.* Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives. Molecules. 24(23), E4316, 2019. doi: 10.3390/molecules24234316.
Fujii Y, Suhara Y, Sukikara Y, Teshima T, Hirota Y, Yoshimura K, Osakabe N.* Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity. Molecules. 24(20), E3667, 2019. doi: 10.3390/molecules24203667.
Hirota Y, Suhara Y.* New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity. Int J Mol Sci. 20(12), E3006, 2019. doi: 10.3390/ijms20123006.
Nakagawa K, Fujiwara K, Nishimura A, Murakami C, Kawamoto K, Ichinose C, Kunitou Y, Suhara Y, Okano T, Hasegawa H.* UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells. Int J Mol Sci. 20(8), E1971, 2019. doi: 10.3390/ijms20081971.
2018年度
Hirota, Y.; Nakagawa, K.; Isomoto, K.; Sasaki, T.; Kubodera, N.; Kamao, M.; Osakabe, N.; Suhara, Y.; Okano, T.* Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice. PLoS One. 13(10), e0199856, 2018. doi: 10.1371/journal.pone.0199856.
Nakagawa, Y.; Ishimura, K.; Oya, S.; Kamino, M.; Fujii, Y.; Nanba, F.; Toda, T.; Ishii, T.; Adachi, T.; Suhara, Y.; Osakabe, N.* Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice. PLoS One. 13(7), e0201203, 2018. doi: 10.1371/journal.pone.0201203.
2017年度
Sakane, R.; Kimura, K.; Hirota, Y.; Ishizawa, M.; Takagi, Y.; Wada, A.; Kuwahara, S.; Makishima, M.; Suhara, Y.* Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities. Bioorg. Med. Chem. Lett. 27(21), 4881-4884, 2017. doi: 10.1016/j.bmcl.2017.09.038.
Kamao, M.; Hirota, Y.; Suhara, Y.; Tsugawa, N.; Nakagawa, K.; Okano, T.; Hasegawa, H.* Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring. Anal Sci. 33(7), 863-867, 2017. doi: 10.2116/analsci.33.863.
Kimura, K.; Hirota, Y.; Kuwahara, S.; Takeuchi, A.; Tode, C.; Wada, A.; Osakabe, N.; Suhara, Y.* Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells. J. Med. Chem. 60(6), 2591-2596, 2017. doi: 10.1021/acs.jmedchem.6b01717.
Ikeda, M.; Ueda-Wakagi, M.; Hayashibara, K.; Kitano, R.; Kawase, M.; Kaihatsu, K.; Kato, N.; Suhara, Y.; Osakabe, N.; Ashida, H.* Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin. Molecules, 22(2), E314, 2017. doi: 10.3390/molecules22020314.
Hirota, Y; Nakagawa, K.; Mimatsu, S.; Sawada, N,.; Sasaki, T.; Kubodera, N.; Kamao, M.; Tsugawa, N.; Suhara, Y.; Okano, T. Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and VDR knockout mice. Biochem. Biophys. Res. Commun. 483 (1), 359-365, 2017. doi: 10.1016/j.bbrc.2016.12.139.
2016年度
SAITO, A.; NAKAZATO, R.; SUHARA, Y.; SHIBATA, M.; FUKUI, T.; ISHII, T.; ASANUMA, T.; MOCHIZUKI, K.; NAKAYAMA, T.; OSAKABE, N. The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials. J. Nutr. Biochem. 107-114, 2016.
KAMIO, N.; SUZUKI, T.; WATANABE, Y.; SUHARA, Y.; OSAKABE, N. A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice. Free Radic. Biol. Med. 256-263, 2016.
2015年度
KUDO, N.; ARAI, Y.; SUHARA, Y.; ISHII, T.; NAKAYAMA, T.; OSAKABE, N. A Single Oral Administration of Theaflavins Increases Energy Expenditure and the Expression of Metabolic Genes. PLos One 10(9), e0137809, 2015.
SUHARA, Y.; HIROTA, Y.; HANADA, N.; NISHINA, S.; EGUCHI, S.; SAKANE, R.; NAKAGAWA, K.; WADA, A.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T. Synthetic small molecules derived from natural vitamin K homologues that induce selective neuronal differentiation of neuronal progenitor cells. J. Med. Chem. 58(17), 7088-7092, 2015.
HIROTA, Y.; NAKAGAWA, K.; SAWADA, N.; OKUDA, N.; SUHARA, Y.; UCHINO, Y.; KIMOTO, T.; FUNAHASHI, N.; KAMAO, M.; TSUGAWA, N.; OKANO, T. Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. PLoS One. 10(4), e0125737, 2015.
FUNAHASHI, N.; HIROTA, Y.; NAKAGAWA, K.; SAWADA, N.; WATANABE, M.; SUHARA, Y.; OKANO, T. YY1 positively regulates human UBIAD1 expression. Biochem. Biophys. Res. Commun. 460(2), 238-244, 2015.
2014年度
NAKAGAWA, K.; SAWADA, N.; HIROTA, Y.; UCHINO, Y.; SUHARA, Y.; HASEGAWA, T.; AMIZUKA, N.; OKAMOTO, T.; TSUGAWA, N.; KAMAO, M.; FUNAHASHI, N.; OKANO, T. Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice. PLoS One, 15;9(8), e104078, 2014.
2013年度
HIROTA, Y.; TSUGAWA, N.; NAKAGAWA, K.; SUHARA, Y.; UCHINO, Y.; TAKEUCHI, A.; SAWADA, N.; KAMAO, M.; WADA, A.; OKITSU, T.; OKANO, T. Menadione (vitamin K3) is not only a catabolic product of oral phylloquinone (vitamin K1) in the intestine but also a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. J. Biol. Chem. 288(46), 33071-33080, 2013.
EDOSON, K.; PSARAD, B.; UNADKAT, J.; SUHARA, Y.; OKANO, T.; GUENGERICH, F.; RETTIE, A. Cytochrome P450-Dependent Catabolism of Vitamin K: ω-Hydroxylation Catalyzed by Human CYP4F2 and CYP4F11. Biochemistry 52, 8276-8285, 2013.
LI, Q.; QI, J.; WU, Y.; KIYOTA, H.; TANAKA, K.; SUHARA, Y.; OHRUI, H.; SUZUKI, Y.; VAVRICKA, C. J.; GAO, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers fuether insight into the mechanism of oseltamivir resistance. J. Virol. 87(16), 10016-10024, 2013.
2012年度
SUHARA, Y.; HANADA, N.; OKITSU, T.; SAKAI, M.; WATANABE, M.; NAKAGAWA, K.; WADA, A.; TAKEDA, K.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T. Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities. J. Med. Chem. 55, 1553-1558, 2012.
2011年度
SUHARA, Y.; WATANABE, M.; MOTOYOSHI, S.; NAKAGAWA, K.; WADA, A.; TAKEDA, K.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T. Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K. J. Med. Chem. 54, 4918-4922, 2011.
SUHARA, Y.; WATANABE, M.; NAKAGWA, K.; WADA, A.; ITO, Y.; TAKEDA, K.; TAKAHASHI, K.; OKANO, T. Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists. J. Med. Chem. 54, 4269-4273, 2011.
2010年度
NAKAGAWA, K.; HIROTA, Y.; SAWADA, N.; YUGE, N.; WATANABE, M.; UCHINO, Y.; OKUDA, N.; SHIMOMURA, Y.; SUHARA, Y.; OKANO, T. Identification of UBIAD1 as a Novel Human Menaquinone-4 Biosynthesis Enzyme. Nature 468, 117-121, 2010.
WADA, A.; WANG, F.; SUHARA, Y.; YAMANO, Y; OKITSU T.; NAKAGAWA, K.; OKANO, T. Efficient Synthesis and Biological Evaluation of Demethyl Geranylgeranoic Acid Derivatives. Bioorg. Med. Chem. 18(16), 5795-5806, 2010.
SUHARA, Y.; WADA, A.; TACHIBANA, Y.; WATANABE, M.; NAKAMURA, K.; NAKAGAWA, K.; OKANO, T. Structure-activity Relationships in the Conversion of Vitamin K Analogues into Menaquinone-4. Substrates Essential to the Synthesis of Menaquinone-4 in Cultured Human Cell Lines. Bioorg. Med. Chem. 18(9), 3116-3124, 2010.
2009年度
SAITO, N.; SUHARA, Y.; ABE, D.; KUSUDO, T.; OHTA, M.; SAKAKI, T.; HONZAWA, S.; FUJISHIMA, T.; KITTAKA, A. Synthesis of 2α-Propoxy-1α,25- dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1. Bioorg. Med. Chem. 17(13), 4296-4301, 2009.
SUHARA, Y.; WADA, A.; OKANO, T. Elucidation of the Mechanism Producing Menaquinone-4 in Osteoblastic Cells. Bioorg. Med. Chem. Lett. 19, 1054-1057, 2009.
SUHARA, Y.; ABE, S.; MURAKAMI, A.; SHIMOMURA, Y.; NAKAGAWA, K.; KAMAO, M.; TUGAWA, N.; OKANO, T. Synthesis and Development of Biologically Active Fluorescent-labeled Vitamin K Analogues and Monitoring of their Subcellular Distribution. Tetrahedron 64, 8789-8796, 2008.
SUHARA, Y.; HIROTA, Y.; NAKAGAWA, K.; KAMAO, M.; TSUGAWA, N.; OKANO, T. Design, Synthesis and Structure-activity Relationship of Vitamin K2 Analogues: Evaluation of their Biological Activities with Human Cultured Cell Lines. Bioorg. Med. Chem. 16(6), 3108-3117, 2008.
OKANO, T.; SHIMOMURA, Y.; YAMANE, M.; SUHARA, Y.; KAMAO, M.; SUGIURA, M.; NAKAGAWA, K. Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE. J. Biol. Chem. 283(17), 11270-11279, 2008.
TSUGAWA, N.; SHIRAKI, M.; SUHARA, Y.; KAMAO, M.; TANAKA, K.; OKANO, T. Vitamin K Status Is Associated with Vertebral Fracture in Japanese Women. J. Bone Miner. Metab. 26(1), 79-85, 2008.
2007年度
KAMAO, M.; TSUGAWA, N.; SUHARA, Y.; WADA, A.; MORI, T.; MURATA, K.; NISHINO, R.; UKITA, T.; UENISHI, K.; TANAKA, K.; OKANO, T. Quantification of Fat-soluble Vitamins in Human Breast Milk by Liquid Chromatography-tandem Mass Spectrometry. J. Chromatogr. B 859, 192-200, 2007.
KAMAO, M.; SUHARA, Y.; TSUGAWA, N.; UWANO, M.; YAMAGUCHI, N.; UENISHI, K.; ISHIDA, H. Vitamin K Content of Foods and Dietary Vitamin K Intake in Japanese Young Women. J. Ntr. Sci. Vitaminol. 53(6), 464-470, 2007.
KAMAO, M.; TSUGAWA, N.; SUHARA, Y.; OKANO, T. Determination of Fat-Soluble Vitamins in Human Plasma, Breast Milk and Food Samples: Application in Nutrition Survey for Establishment of “Dietary Reference Intakes for Japanese”. J. Health Sci. 53(3), 257-262, 2007.
SUHARA, Y.; MURAKAMI, A.; KAMAO, M.; NAKAGAWA, K.; TSUGAWA, N.; OKANO, T. Efficient Synthesis and Biological Evaluation of ω-Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites. Bioorg. Med. Chem. Lett. 17, 1622-1625, 2007.
SUHARA, Y.; OKA, S.; KITTAKA, A.; TAKAYAMA, H.; WAKU, K.; SUGIURA, T. Synthesis and Biological Evaluation of Several Structural Analogs of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand. Bioorg. Med. Chem. 15, 854-867, 2007.
TAKAHASHI, E.; NAKAGAWA, K.; SUHARA, Y.; KITTAKA, A.; NIHEI, K.; KONNO, K.; TAKAYAMA, H.; OKANO, T. Biological Activities of 2α-Substituted Analogues of 1α,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation. Biol. Pharm. Bull. 29(11), 2246-2250, 2006.
HOURAI, S.; FUJISHIMA, T.; KITTAKA, A.; SUHARA, Y.; TAKAYAMA, H.; ROCHEL, N.; MORAS, D. Probing a Water Channel near the A-Ring of Receptor-Bound 1α,25-Dihydroxyvitamin D3 with Selected 2α-Substituted Analogues. J. Med. Chem. 49(17), 5199-5205, 2006.
SUHARA, Y.; MURAKAMI, A.; NAKAGAWA, K.; MIZUGUCHI, Y.; OKANO, T. Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines. Bioorg. Med. Chem. 14, 6601-6607, 2006.
SUHARA, Y.; KURIHARA, M.; KITTAKA, A.; ICHIKAWA, Y. Efficient Synthesis of Carbopeptoid Oligomers: Insight into Mimicry of β-Peptide. Tetrahedron 62, 8207-8217, 2006.
TSUGAWA, N.; SHIRAKI, M.; SUHARA, Y.; KAMAO, M.; TANAKA, K.; OKANO, T. Vitamin K Status of Healthy Japanese Women; Age-related Vitamin K Requirement for γ-Carboxylation of Osteocalcin. Am. J. Clin. Nutr. 83, 380-386, 2006.
2005年度
ABE, D.; SAKAKI, T.; KUSUDO, T.; KITTAKA, A.; SAITO, N.; SUHARA, Y.; FUJISHIMA, T.; TAKAYAMA, H.; HAMAMOTO, H.; KAMAKURA, M.; OHTA, M.; INOUYE, K. 2α-Propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-Hydroxypropoxy)-1α,25 -dihydroxyvitamin D3 by Human CYP27A1 and CYP24A1. Drug Metab. Dispos. 33(6), 778-784, 2005.
TSUGAWA, N.; SUHARA, Y.; KAMAO, M.; OKANO, T. Method for the Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem. 77(9), 3001-3007, 2005.
KAMAO, M.; SUHARA, Y.; TSUGAWA, N.; OKANO, T. Determination of plasma vitamin K by high-performance liquid chromatography with fluorescence detection using vitamin K analogs as internal standards. J. Chromatogr. B. 816(1-2), 41-48, 2005.
SUHARA, Y.; KAMAO, M.; TSUGAWA, N.; OKANO, T. Method for the Detection of Vitamin K Homologues in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem. 77(3), 757-763, 2005.
2004年度
SAITO, N.; SUHARA, Y.; KURIHARA, M.; FUJISHIMA, T.; HONZAWA, S.; TAKAYANAGI, H.; KOZONO, T.; MATSUMOTO, M.; OHMORI, M.; MIYATA, N.; TAKAYAMA, H.; KITTAKA, A. Design and Efficient Synthesis of 2α-(α-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity. J. Org. Chem. 69(22), 7463-7471, 2004.
SUHARA, Y.; ONO, K.; YOSHIDA, A.; FUJISHIMA, T.; SAITO, N.; HONZAWA, S.; KISHIMOTO, S.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H.; KITTAKA, A. Synthesis of Novel 1α,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate. Heterocycles 62, 423-436, 2004.
2003年度
HONZAWA, S.; SUHARA, Y.; NIHEI, K.; SAITO, N.; KISHIMOTO, S.; FUJISHIMA, T.; KURIHARA, M.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H.; KITTAKA, A. Concise Synthesis and Biological Activities of 2α-Alkyl- and 2α-(α-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3. Bioorg. Med. Chem. Lett. 13(20), 3503-3506, 2003.
ONO, K.; YOSHIDA, A.; SAITO, N.; FUJISHIMA, T.; HONZAWA, S.; SUHARA, Y.; KISHIMOTO, S.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H.; KITTAKA, A. Efficient Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells. J. Org. Chem. 68(19), 7407-7415, 2003.
YOSHIDA, A.; ONO, K.; SUHARA, Y.; SAITO, N.; TAKAYAMA, H.; KITTAKA, A. Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2α- and 2α-Alkylated 1α,25-Dihydroxy-19-norvitamin D3 Analogues. Synlett (8), 1175-1179, 2003.
OKA, S.; TSUCHIE, A.; TOKUMURA, A.; MURAMATSU, M.; SUHARA, Y.; TAKAYAMA, H.; WAKU, K.; SUGIURA, T. Ether-linked Analogue of 2-Arachidonoylglycerol (Noladin ether) was not Detected in the Brains of Various Mammalian Species. J. Neurochem. 85, 1374-1381, 2003.
KITTAKA, A.; KURIHARA, M.; PLEG, S.; SUHARA, Y.; TAKAYAMA, H. 2α-(3-Hydroxypropyl)- and 2α-(3-Hydroxypropyl)-1α,25-dihydroxyvitaminD3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets. Chem. Pharm. Bull. 51(3), 357-8, 2003.
2002年度
SUHARA, Y.; KITTAKA, A.; ONO, K.; FUJISHIMA, T.; YOSHIDA, A.; TAKAYAMA, H. Design and Efficient Syntheses of New Stable 1α,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond. Bioorg. Med. Chem. Lett. 12, 3533-3536, 2002.
SUHARA, Y.; KITTAKA, A.; KISHIMOTO, S.; CALVERLEY, J. M.; FUJISHIMA, T.; SAITO, N.; SUGIURA, T.; WAKU, K.; TAKAYAMA, H. Synthesis and Testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity. Bioorg. Med. Chem. Lett. 12, 3255-3258, 2002.
SUHARA, Y.; YAMAGUCHI, Y.; COLLINS, B.; SCHNAAR, R. L.; YANAGISHITA, M.; HILDRETH, J. E. K.; SHIMADA, I.; ICHIKAWA, Y. Oligomers of Glycamino Acid. Bioorg. Med. Chem. 10(6), 1999-2013, 2002.
2001年度
SUHARA, Y.; NIHEI, K.; KURIHARA, M.; KITTAKA, A.; YAMAGUCHI, K.; FUJISHIMA, T.; KONNO, K.; MIYATA, N.; TAKAYAMA, H. Efficient and Versatile Synthesis of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors. J.Org.Chem. 66(26), 8760-8771, 2001.
SUHARA, Y.; NAKANE, S.; ARAI, S.; TAKAYAMA, H.; WAKU, K.; ISHIMA, Y.; SUGIURA, T. Synthesis and Biological Activities of Novel Structural Analogues of 2-Arachidonoylglycerol, An Endogenous Cannabinoid Receptor Ligand. Bioorg. Med. Chem. Lett. 11, 1985-1988, 2001.
2000年度
KITTAKA, A.; SUHARA, Y.; TAKAYANAGI, H.; FUJISHIMA, T.; TAKAYAMA, H. A Concise and Efficient Route to 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor. Org. Lett. 2, 2619-2622, 2000.
SUHARA, Y.; TAKAYAMA, H.; NAKANE, S.; MIYASHITA, T.; WAKU, K.; SUGIURA, T. Synthesis and Biological Activities of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, and Its Metabolically Stable Ether-linked Analogues. Chem. Pharm. Bull. 48(7), 903-907, 2000.
SUHARA, Y.; NIHEI, K.; TANIGAWA, H.; FUJISHIMA, T.; KONNO, K.; NAKAGAWA, K.; OKANO, T.; TAKAYAMA, H. Synthesis and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues. Bioorg. Med. Chem. Lett. 10, 1129-1132, 2000.
SUGIURA, T.; KONDO, S.; KISHIMOTO, S.; MIYASHITA, T.; NAKANE, S.; KODAKA, T.; SUHARA, Y.; TAKAYAMA, H.; WAKU, K. Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannnabinoid CB2 Receptor. J. Biol. Chem. 275(1), 605-612, 2000.
1999年度
SUGIURA, T.; KODAKA, T.; NAKANE, S.; MIYASHITA, T.; KONDO, S.; SUHARA, Y.; TAKAYAMA, H.; WAKU, K.; SEKI, C.; BABA, N.; ISHIMA, Y. Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor. J. Biol. Chem. 274(5), 2794-2801, 1999.
1998年度
IZUMI, M.; SUHARA, Y.; ICHIKAWA, Y. Design and Synthesis of Potential Inhibitors of Golgi Endo-α-D-mannosidase: 5-Thio-D-glucopyranosyl-α(1➝3)-1-deoxymannojirimycin and Methyl 5-Thio-D-glucopyranosyl-α(1➝3)-5-thio-α-D-mannopyranoside. J. Org. Chem. 63, 4811-4816, 1998.
ICHIKAWA, Y.; IGARASHI, Y.; ICHIKAWA, M.; SUHARA, Y. 1-N-Iminosugars: Potent and Selective Inhibitors of β-Glycosidases. J. Am. Chem. Soc. 120(13), 3007-3018, 1998.
1997年度
SUHARA, Y.; IZUMI, M.; ICHIKAWA, M.; PENNO, M.B.; ICHIKAWA, Y. Peptide-Sugar Hybrid: Like Peptide, Like Oligosaccharide. Tetrahedron Lett. 38, 7167-7170, 1997.
1996年度
SUHARA, Y.; ICHIKAWA, M.; HILDRETH, J. E. K.; ICHIKAWA, Y. Synthesis of Sulfated β-1,6-Linked Oligosaccharide Mimetics: A Novel Potent Inhibitor of HIV Replication. Tetrahedron Lett. 37, 2549-2552, 1996.
SUHARA, Y.; HILDRETH, J. E. K.; ICHIKAWA, Y. Synthesis of a New Carbohydrate Mimetics: “Carbopeptoid” Containing a C-1 Carboxylate and C-2 Amino Group. Tetrahedron Lett. 37, 1575-1578, 1996.
SHIMIZU, T.; IWAMOTO, Y.; YANAGIHARA, Y.; RYOYAMA, K.; SUHARA, Y.; IKEDA, K.; ACHIWA, K. Comparison of the Biological Activity of Synthetic N-Acylated Asparagine or Serine Linked Monosaccharide Lipid A Analogues. Immunobiology 196(4), 321-331, 1996.
1995年度
SUHARA, Y.; ACHIWA, K. Disaccharides as Endomannosidase Inhibitors: Synthesis of α-Homomannojirimycin and β-Homomannojirimycin Linked to D-Glucose and D-Mannose. Chem. Pharm. Bull. 43, 414-420, 1995.
1994年度
SUHARA, Y.; ARAKAWA, M.; IKEDA, K.; ACHIWA, K. Lipid A and Related Compounds. XXIX.: Synthesis of Biologically Active N-Acylated L-Asparagine-Containing D-Glucosamine Derivatives Structually Related to Lipid A. Chem. Pharm. Bull. 42, 2526-2531, 1994.
SUGIYAMA, K.; UEDA, H.; SUHARA, Y.; KAJIMA, Y.; ICHIO, Y.; YOKOTA, M. Protective Effect of Sodium L-Malate, an Active Constituent Isolated from Angelicae Radix, on cis-Diamminedichloroplatinum (II)-Induced Toxic Side Effect. Chem. Pharm. Bull. 42, 2565-2568, 1994.